Clinical Research

(M.Sc.)

The Dresden International University (DIU) Master’s Program in Clinical Research (MPCR) is designed to provide training in the methodology and practice of clinical research. It creates an international platform for medical scientists which is strongly based on teamwork, creativity, out-of-the-box-thinking and multidisciplinary collaboration.

"Principles and Practice of Clinical Research (PPCR)" is an international nine-month distance-learning program offered by the Harvard TH Chan School of Public Health*. Thanks to our cooperation with Harvard, DIU recognizes all grades and achievements obtained during the PPCR program as equivalent to ECTS. Graduates of the PRCR course can directly continue with our Master’s program and shorten their study time. In the end students receive the academic title Master of Science (M. Sc.) from the Dresden International University.

Our lecturers do not just give teacher centered lectures but rather collaborate with you to generate new ideas and research questions, develop new thinking strategies and help you further develop your individual skills. This unique and very close and open relationship between students and teachers is also a mutually beneficial way of exchanging ideas and creating a strong professional network.

In addition to the theoretical background, we enable our students to apply the practical aspects of clinical research. The negotiation of contracts and the independent development and implementation of clinical research projects have priority. The evaluation of chances and risks of a project as well as the interpretation and evaluation of the effects which can result from the clinical study are essential for the MPCR study course.

*For a detailed program of the PPCR course, please visit www.hsph.me/ppcr

Overview of the study contents

  1. Basics of Clinical Research
    • Introduction to Clinical Trials
    • Selection of the Question
    • Study Population
    • Basic Study Design
    • Ethical and Regulatory Issues
    • Study Blinding
    • The Randomization Process
    • Recruitment of Study Participants
    • Participant Adherence
  2. Statistics
    • Statistics – Basics
    • Statistical Tests I+II
    • Sample Size
    • Survival Analysis
    • Other Issues in Statistics I+II
  3. Practical Aspects of Clinical Research
    • ntegrity in Research
    • The Business of Clinical Research
    • Being a Clinical and Translational Scientist: Practical Challenges and Recommendations
    • Design and Analysis of Surveys
    • Assessing Risk and Adverse Effects bin Clinical Research
    • Phase III and Multicenter Trials
    • Manuscript Submission
  4. Study Designs
    • International/Global Research
    • Special Panel: RCT vs. Observational Designs – How to choose?
    • Observational Studies
    • Confounders in Observational Studies: Using the Method of Propensity Score
    • Designs with Medical Devices and Interim Analysis
    • Non-Inferiority Designs
  5. Workshops
    • Review and discussion of material presented throughout the year in a detailed and intensive fashion.
  6. Research Organization and presentation
    • Clinical Pharmacological Trials
    • Financial and Economic Aspects of Clinical Research

After finishing these modules students will complete their Master's Thesis on a topic in the field of Clinical Research supervised by lecturers of the Master's Program.

Lecturers

Teaching Staff

Our faculty and staff are internationally recognized for their teaching in clinical research.

Lecturers (excerpt)

  • PD Dr. med. habil. Timo Siepmann, Attending physician, Project director, Medical Education Program MEDiC (TU Dresden), Site Director, Principles and Practice of Clinical Research (Harvard TH Chan School of Public Health), Department of Neurology, Universitätsklinikum Carl Gustav Carus Dresden, Technische Universität Dresden
  • Ben Illigens, MD
  • Marc Eisele, Director Centre for Media Technology in Medicine, Carl Gustav Carus University Hospital
  • Ingeborg Friehs, MD, Instructor in Surgery Department of Cardiac Surgery Children's Hospital Boston, Harvard Medical School, Boston United States
  • Prof. Dr. med. Martin Siepmann, Professor of Clinical Pharmacology Neurologist (board certified), Psychiatrist (board certified), Clinical Pharmacologist (board certified), Psychosomatician (board certified) Carl Gustav Carus University Hospital Technische Universität Dresden and Director Department of Psychosomatic Medicine and Psychotherapy Rhoen Hospital Bad Neustadt Dresden and Bad Kissingen, Germany
  • Grace Yu, PhD, Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) University of Oxford, Oxford United Kingdom
  • Prof. Dr. Bernhard Schipp, Professor of Business and Economics Quantitative Methods, esp. Econometrics, Technische Universität Dresden, Dresden Germany
  • Alexandra Pintér, MD, PhD, Assistant professor of physiology Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest Hungary

Teaching Assistants (TA)

  • Miluska Bromley, MD, MSc, Senior TA, Plastic and Reconstructive Surgery Resident
  • Mohamed Hashim Mahmoud, MD, ABHS-FM, Family Medicine, West Bay Training Center, Doha - Qatar
  • Arturo Tamayo, MD, FAHA, Assistant Professor of Neurology University of Manitoba

Publications

In our Master’s program the majority of theses are publications in international peer-reviewed journals.

List of selected publications:

  • Uema D, Alves C, Mesquita M, Nuñez JE, Siepmann T, Angel M, Rego JFM, Weschenfelder R, Rocha Filho DR, Costa FP, Barros M, O'Connor JM, Illigens BM, Riechelmann RP Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study. J Clin Med. 2019 Mar 23;8(3)
     
  • Sofiyeva N, Siepmann T, Barlinn K, Seli E, Ata B. Gonadotropin-Releasing Hormone Analogs for Gonadal Protection During Gonadotoxic Chemotherapy: A Systematic Review and Meta-Analysis. Reprod Sci. 2019 Jul;26(7):939-953
     
  • Fasslrinner F, Schetelig J, Burchert A, Kramer M, Trenschel R, Hegenbart U, Stadler M, Schäfer-Eckart K, Bätzel M, Eich H, Stuschke M, Engenhart-Cabillic R, Krause M, Dreger P, Neubauer A, Ehninger G, Beelen D, Berdel WE, Siepmann T, Stelljes M, Bornhäuser M. Long-term efficacy of reduced-intensity versus myeloablative conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: retrospective follow-up of an open-label, randomised phase 3 trial. Lancet Haematol. 2018;5(4):e161-e169
     
  • Heppt MV, Siepmann T, Engel J, Schubert-Fritschle G, Eckel R, Mirlach L, Kirchner T, Jung A, Gesierich A, Ruzicka T, Flaig MJ, Berking C. Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routine care. BMC Cancer. 2017;17(1):536
     
  • Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-analysis. Riediger C, Schuster T, Barlinn K, Maier S, Weitz J, Siepmann T. Front Neurol. 2017;8:307
     
  • Schnabel A, Range U, Hahn G, Siepmann T, Berner R, Hedrich CM. Unexpectedly high incidences of chronic non-bacterial as compared to bacterial osteomyelitis in children. Rheumatol Int. 2016;36(12):1737-1745
     
  • Nassir M, Guan J, Luketina H, Siepmann T, Rohr I, Richter R, Castillo-Tong DC, Zeillinger R, Vergote I, Van Nieuwenhuysen E, Concin N, Marth C, Hall C, Mahner S, Woelber L, Sehouli J, Braicu EI. The role of HE4 for prediction of recurrence in epithelial ovarian cancer patients - results from the OVCAD study. Tumour Biol 2016;37(3):3009-3016
     
  • Raspe M, Müller-Marbach A, Schneider M, Siepmann T, Schulte K. Work and training conditions of young German physicians in internal medicine. Results of a nationwide survey by young internists from the German Society of Internal Medicine and the German Professional Association of Internists. Dtsch Med Wochenschr 2016;141(3):202-210
     
  • Kepplinger J, Prakapenia A, Barlinn K, Siegert G, Gehrisch S, Zerna C, Beyer-Westendorf J, Puetz V, Reichmann H, Siepmann T, Bodechtel U. Standardized use of novel oral anticoagulants plasma level thresholds in a new thrombolysis decision making protocol. J Thromb Thrombolysis2016;41(2):293-300
     
  • Lohkamp L, Öllinger R, Chatzigeorgiou A, Illigens BM, Siepmann T. Intraoperative biomarkers in renal transplantation. Nephrology (Carlton). 2016;21(3):188-199
     
  • Spieth PM, Kubasch AS, Penzlin AI, Illigens BM, Barlinn K, Siepmann T. Randomized controlled trials - a matter of design. Neuropsychiatr Dis Treat 2016;12:1341-1349
     
  • Gehring C, Siepmann T, Heidegger H, Jeschke U. The controversial role of human chorionic gonadotropin in the development of breast cancer and other types of tumors. Breast. 2016;26:135-140
     
  • Zerna C, Siepmann T, Barlinn K, Kepplinger J, Pallesen LP, Puetz V, Bodechtel U. Association of time on outcome after intravenous thrombolysis in the elderly in a telestroke network. J Telemed Telecare 2016;22(1):18-24
     
  • Barlinn K, Kepplinger J, Puetz V, Illigens BM, Bodechtel U, Siepmann T. Exploring the risk-factor association between depression and incident stroke: a systematic review and meta-analysis. Neuropsychiatr Dis Treat 2015,11:1-14
     
  • Woopen H, Richter R, Chekerov R, Siepmann T, Ismaeel F, Sehouli J. The influence of comorbidity and comedication on grade III/IV toxicity and prior discontinuation of chemotherapy in recurrent ovarian cancer patients: An individual participant data meta-analysis of the North-Eastern German Society of Gynecological Oncology (NOGGO). Gynecol Oncol 2015;138(3):735-740
     
  • Seidlitz A, Siepmann T, Löck S, Juratli T, Baumann M, Krause M. Impact of waiting time after surgery and overall time of postoperative radiochemotherapy on treatment outcome in glioblastoma multiforme. Radiat Oncol 2015:10:172