Clinical Research (M.Sc.)

List of selected publications:

• Serrano-Castro ML, Garro-Zúñiga M, Simon E, Tamayo A, Siepmann T. Clinical and Imaging Phenotypes and Outcomes in a Costa Rican Cohort of Acute Ischemic Stroke Survivors: A Retrospective Study. J Clin Med. 2023 Jan 30;12(3):1080. doi: 10.3390/jcm12031080. PMID: 36769728; PMCID: PMC9917829.
• Eckardt JN, Stasik S, Röllig C, Sauer T, Scholl S, Hochhaus A, Crysandt M, Brümmendorf TH, Naumann R, Steffen B, Kunzmann V, Einsele H, Schaich M, Burchert A, Neubauer A, Schäfer-Eckart K, Schliemann C, Krause SW, Herbst R, Hänel M, Hanoun M, Kaiser U, Kaufmann M, Rácil Z, Mayer J, Cerqueira T, Kroschinsky F, Berdel WE, Serve H, Müller-Tidow C, Platzbecker U, Baldus CD, Schetelig J, Siepmann T, Bornhäuser M, Middeke JM, Thiede C. Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome. Blood Cancer J. 2023 Jan 24;13(1):18. doi: 10.1038/s41408-023-00790-1. PMID: 36693840; PMCID: PMC9873811.
• Conde Monroy D, Ibañez-Pinilla M, Sabogal JC, Rey Chaves C, Isaza-Restrepo A, Girón F, Vanegas M, Ibañez-Villalba R, Mirow L, Siepmann T. Survival Outcomes of Hepatectomy in Gastric Cancer Liver Metastasis: A Systematic Review and Meta-Analysis. J Clin Med. 2023 Jan 16;12(2):704. doi: 10.3390/jcm12020704. PMID: 36675632; PMCID: PMC9861719.
• Hackner D, Hobbs M, Merkel S, Siepmann T, Krautz C, Weber GF, Grützmann R, Brunner M. Impact of Patient Age on Postoperative Short-Term and Long-Term Outcome after Pancreatic Resection of Pancreatic Ductal Adenocarcinoma. Cancers (Basel). 2022 Aug 15;14(16):3929. doi: 10.3390/cancers14163929. PMID: 36010922; PMCID: PMC9406071.
• Lincango Naranjo EP, Garces-Delgado E, Siepmann T, Mirow L, Solis-Pazmino P, Alexander-Leon H, Restrepo-Rodas G, Mancero-Montalvo R, Ponce CJ, Cadena-Semanate R, Vargas-Cordova R, Herrera-Cevallos G, Vallejo S, Liu-Sanchez C, Prokop LJ, Ziogas IA, Vailas MG, Guerron AD, Visser BC, Ponce OJ, Barbas AS, Moris D. Robotic Living Donor Right Hepatectomy: A Systematic Review and Meta-Analysis. J Clin Med. 2022 May 5;11(9):2603. doi: 10.3390/jcm11092603. PMID: 35566727; PMCID: PMC9103024.
• Freitas V, Li X, Amitai Y, Au F, Kulkarni S, Ghai S, Mulligan AM, Bromley M, Siepmann T. Contralateral Breast Screening with Preoperative MRI: Long-Term Outcomes for Newly Diagnosed Breast Cancer. Radiology. 2022 Aug;304(2):297-307. doi: 10.1148/radiol.212361. Epub 2022 Apr 26. PMID: 35471109.
• Hackner D, Hobbs M, Merkel S, Siepmann T, Krautz C, Weber GF, Grützmann R, Brunner M. Impact of Patient Age on Postoperative Short-Term and Long-Term Outcome after Pancreatic Resection of Pancreatic Ductal Adenocarcinoma. Cancers (Basel). 2022 Aug 15;14(16):3929. doi: 10.3390/cancers14163929. PMID: 36010922; PMCID: PMC9406071.
• Aabdien M, Abdallah I, Bougmiza MI, Siepmann T, Illigens B. Perceptions and attitudes toward participation in clinical research in the Eastern Mediterranean Region: A systematic review. Medicine (Baltimore). 2022 Aug 19;101(33):e29959. doi: 10.1097/MD.0000000000029959. PMID: 35984206; PMCID: PMC9388020.
• Grigorescu M, Kemmner S, Schönermarck U, Sajin I, Guenther W, Cerqueira TL, Illigens B, Siepmann T, Meiser B, Guba M, Fischereder M, Stang MJ. Disqualification of Donor and Recipient Candidates From the Living Kidney Donation Program: Experience of a Single-Center in Germany. Front Med (Lausanne). 2022 Jun 10;9:904795. doi: 10.3389/fmed.2022.904795. PMID: 35755074; PMCID: PMC9226311.
• Lincango Naranjo EP, Garces-Delgado E, Siepmann T, Mirow L, Solis-Pazmino P, Alexander-Leon H, Restrepo-Rodas G, Mancero-Montalvo R, Ponce CJ, Cadena-Semanate R, Vargas-Cordova R, Herrera-Cevallos G, Vallejo S, Liu-Sanchez C,
• Prokop LJ, Ziogas IA, Vailas MG, Guerron AD, Visser BC, Ponce OJ, Barbas AS, Moris D. Robotic Living Donor Right Hepatectomy: A Systematic Review and Meta-Analysis. J Clin Med. 2022 May 5;11(9):2603. doi: 10.3390/jcm11092603. PMID: 35566727; PMCID: PMC9103024.
• Yousaf Z, Ata F, Chaudhary H, Krause F, Illigens BM, Siepmann T. Etiology, pathological characteristics, and clinical management of black pleural effusion: A systematic review. Medicine (Baltimore). 2022 Feb 25;101(8):e28130. doi:10.1097/MD.0000000000028130. PMID: 35212269; PMCID: PMC8878788.
• Schmidt MW, Battista MJ, Schmidt M, Garcia M, Siepmann T, Hasenburg A, Anic K. Efficacy and Safety of Immunotherapy for Cervical Cancer-A Systematic Review of Clinical Trials. Cancers (Basel). 2022 Jan 17;14(2):441. doi: 10.3390/cancers14020441. PMID: 35053603; PMCID: PMC8773848.
• Eltemamy MA, Tamayo A, Altarsha E, Sedghi A, Pallesen LP, Barlinn J, Puetz V, Illigens BM, Barlinn K, Siepmann T. erebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients. Front Neurol. 2021 Nov 12;12:736818.
• doi: 10.3389/fneur.2021.736818. PMID: 34867720; PMCID: PMC8632802.
• Tamayo A, Siepmann T. Regulation of Blood Flow in the Cerebral Posterior Circulation by Parasympathetic Nerve Fibers: Physiological Background and Possible Clinical Implications in Patients With Vertebrobasilar Stroke. Front Neurol. 2021 Oct 29;12:660373. doi: 10.3389/fneur.2021.660373. PMID: 34777191; PMCID: PMC8585859.
• Marin-Concha J, Rengifo P, Tapia P, Kaiser D, Siepmann T. Prevalence and characteristics of the aberrant anterior tibial artery: a single-center magnetic resonance imaging study and scoping review. BMC Musculoskelet Disord. 2021 Nov
• 2;22(1):922. doi: 10.1186/s12891-021-04801-9. PMID: 34727902; PMCID: PMC8564972.
• Vorisek CN, Zurakowski D, Tamayo A, Axt-Fliedner R, Siepmann T, Friehs I. Postnatal circulation in patients with aortic stenosis undergoing fetal aortic valvuloplasty: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2022 May;59(5):576-584. doi: 10.1002/uog.24807. Epub 2022 Apr 11. PMID: 34726817.
• Mohamed MFH, Danjuma M, Mohammed M, Mohamed S, Siepmann M, Barlinn K, Suwileh S, Abdalla L, Al-Mohanadi D, Silva Godínez JC, Elzouki AN, Siepmann T. Myxedema Psychosis: Systematic Review and Pooled Analysis. Neuropsychiatr Dis Treat. 2021 Aug 18;17:2713-2728. doi: 10.2147/NDT.S318651. PMID: 34447249; PMCID: PMC8382967.
• Farina A, Moro F, Fasslrinner F, Sedghi A, Bromley M, Siepmann T. Strength of clinical evidence leading to approval of novel cancer medicines in Europe: A systematic review and data synthesis. Pharmacol Res Perspect. 2021 Aug;9(4):e00816. doi: 10.1002/prp2.816. PMID: 34232554; PMCID: PMC8262606.
• Hajelssedig OE, Zorron Cheng Tao Pu L, Thompson JY, Lord A, El Sayed I, Meyer C, Shaukat Ali F, Abdulazeem HM, Kheir AO, Siepmann T, Singh R. Diagnostic accuracy of narrow-band imaging endoscopy with targeted biopsies compared with standard endoscopy with random biopsies in patients with Barrett's esophagus: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2021 Oct;36(10):2659-2671. doi: 10.1111/jgh.15577. Epub 2021 Jul 5. PMID: 34121232.
• Soldatelli MD, Siepmann T, Illigens BM, Souza Dos Santos V, Lucena da S Torres I, Fregni F, Caumo W. Mapping of predictors of the disengagement of the descending inhibitory pain modulation system in fibromyalgia: an exploratory study. Br J Pain. 2021 May;15(2):221-233. doi: 10.1177/2049463720920760. Epub 2020 May 30. PMID: 34055343; PMCID: PMC8138619.
• Struja T, Koch D, Haubitz S, Mueller B, Schuetz P, Siepmann T. Quality of life after hospitalization predicts one-year readmission risk in a large Swiss cohort of medical in-patients. Qual Life Res. 2021 Jul;30(7):1863-1871. doi: 10.1007/s11136-021-02867-5. Epub 2021 May 18. PMID: 34003435.
• Hassan WM, Bakry MS, Siepmann T, Illigens B. Association of RASSF1A, DCR2, and CASP8 Methylation with Survival in Neuroblastoma: A Pooled Analysis Using Reconstructed Individual Patient Data. Biomed Res Int. 2020 Dec 15;2020:7390473. doi: 10.1155/2020/7390473. PMID: 33381579; PMCID: PMC7755470.
• Inci MG, Richter R, Woopen H, Rasch J, Heise K, Anders L, Mueller K, Nasser S, Siepmann T, Sehouli J. Role of predictive markers for severe postoperative complications in gynecological cancer surgery: a prospective study (RISC-GynTrial). Int J Gynecol Cancer. 2020 Dec;30(12):1975-1982. doi: 10.1136/ijgc-2020-001879. Epub 2020 Nov 27. PMID: 33246921.
• Kutz A, Ebrahimi F, Aghlmandi S, Wagner U, Bromley M, Illigens B, Siepmann T, Schuetz P, Mueller B, Christ-Crain M. Risk of Adverse Clinical Outcomes in Hyponatremic Adult Patients Hospitalized for Acute Medical Conditions: A Population-Based Cohort Study. J Clin Endocrinol Metab. 2020 Nov 1;105(11):3428–36. doi: 10.1210/clinem/dgaa547. PMID: 32818232; PMCID: PMC7500475.
• Lopes DG, Tamayo A, Schipp B, Siepmann T. Cost-effectiveness of edoxaban vs low-molecular-weight heparin and warfarin for cancer-associated thrombosis in Brazil. Thromb Res. 2020 Dec;196:4-10. doi: 10.1016/j.thromres.2020.08.014. Epub 2020 Aug 11. PMID: 32810773.
• Ebrahimi F, Kutz A, Wagner U, Illigens B, Siepmann T, Schuetz P, Christ-Crain M, Mueller B, Christ ER. Excess Mortality Among Hospitalized Patients With Hypopituitarism-A Population-Based, Matched-Cohort Study. J Clin Endocrinol Metab. 2020 Nov 1;105(11):dgaa517. doi: 10.1210/clinem/dgaa517. PMID: 32785679.
• Scheel-Sailer A, Sailer CO, Lampart P, Baumberger M, Berger M, Mueller G, Sigrist-Nix D, Schmitt K, Siepmann T, Pannek J. Examinations and assessments in patients with a newly acquired spinal cord injury - retrospective chart analysis as part of a quality improvement project. Swiss Med Wkly. 2020 Jul 30;150:w20291. doi: 10.4414/smw.2020.20291. PMID: 32730632.
• Mohamed MFH, Siepmann T, Suwileh S, Mohammed MH, Mohamed S, Abdalla LO, Elzouki AN, Mahmoud MH, Al-Mohanadi D, Danjuma M. Myxedema psychosis: A protocol for a systematic review and a pooled analysis. Medicine (Baltimore). 2020 Jun 26;99(26):e20778. doi: 10.1097/MD.0000000000020778. PMID: 32590756; PMCID: PMC7328932.
• Cosgarea I, Griewank KG, Ungureanu L, Tamayo A, Siepmann T. Deep Penetrating Nevus and Borderline-Deep Penetrating Nevus: A Literature Review. Front Oncol. 2020 May 20;10:837. doi: 10.3389/fonc.2020.00837. PMID: 32509588; PMCID:PMC7251176.
• Ruiz Segura LT, Figueroa Pérez E, Nowak-Wegrzyn A, Siepmann T, Larenas-Linnemann D. Food allergen sensitization patterns in a large allergic population in Mexico. Allergol Immunopathol (Madr). 2020 Nov-Dec;48(6):553-559. doi: 10.1016/j.aller.2020.02.004. Epub 2020 May 20. PMID: 32444115.
• Klein J, Siepmann T, Schackert G, Ziemssen T, Juratli TA. Peripheral nerve field stimulation in medically refractory trigeminal neuralgia attributed to multiple sclerosis. J Neurosurg. 2020 Mar 20;134(3):1244-1250. doi: 10.3171/2019.12.JNS192261. PMID: 32197243.
• daSilva-deAbreu A, Zhao Y, Serauto-Canache A, Alhafez B, Aribindi K, Balan P, Loyalka P, Kaaaar B, Smalling R, Anderson HV, Dhoble A, Siepmann T, Arain SA. Predictors and Prognostic Impact of In-hospital Bleeding after TranscatheterAortic Valve Replacement According to BARC and VARC-2 Definitions. Braz J Cardiovasc Surg. 2019 Dec 1;34(6):788-790. doi: 10.21470/1678-9741-2019-0275. PMID: 31793259; PMCID: PMC6894019.
• Negrão de Figueiredo G, Mueller-Peltzer K, Schwarze V, Marschner C, Zhang L, Rübenthaler J, Siepmann T, Illigens BW, Clevert DA. Long-term study analysis of contrast-enhanced ultrasound in the diagnosis of focal nodular hyperplasia. Clin Hemorheol Microcirc. 2020;74(4):441-452. doi: 10.3233/CH-190710. PMID: 31743989.
• Salguero MV, Al-Obaide MAI, Singh R, Siepmann T, Vasylyeva TL. Dysbiosis of Gram-negative gut microbiota and the associated serum lipopolysaccharide exacerbates inflammation in type 2 diabetic patients with chronic kidneydisease. Exp Ther Med. 2019 Nov;18(5):3461-3469. doi: 10.3892/etm.2019.7943. Epub 2019 Aug 26. PMID: 31602221; PMCID: PMC6777309.
• Yousif D, Bellos I, Penzlin AI, Hijazi MM, Illigens BM, Pinter A, Siepmann T. Autonomic Dysfunction in Preeclampsia: A Systematic Review. Front Neurol. 2019 Aug 6;10:816. doi: 10.3389/fneur.2019.00816. PMID: 31447757; PMCID: PMC6691156.
• Fleischmann DF, Unterrainer M, Corradini S, Rottler M, Förster S, la Fougère C, Siepmann T, Schwaiger M, Bartenstein P, Belka C, Albert NL, Niyazi M. Report of first recurrent glioma patients examined with PET-MRI prior to re-irradiation. PLoS One. 2019 Jul 24;14(7):e0216111. doi: 10.1371/journal.pone.0216111. PMID: 31339892; PMCID: PMC6655559.
• Pinter A, Szatmari S Jr, Horvath T, Penzlin AI, Barlinn K, Siepmann M, Siepmann T. Cardiac dysautonomia in depression - heart rate variability biofeedback as a potential add-on therapy. Neuropsychiatr Dis Treat. 2019 May 17;15:1287-1310. doi: 10.2147/NDT.S200360. PMID: 31190834; PMCID: PMC6529729.
• Mendoza-Velásquez JJ, Flores-Vázquez JF, Barrón-Velázquez E, Sosa-Ortiz AL, Illigens BW, Siepmann T. Autonomic Dysfunction in α-Synucleinopathies. Front Neurol. 2019 Apr 12;10:363. doi: 10.3389/fneur.2019.00363. PMID: 31031694; PMCID: PMC6474181.
• Uema D, Alves C, Mesquita M, Nuñez JE, Siepmann T, Angel M, Rego JFM, Weschenfelder R, Rocha Filho DR, Costa FP, Barros M, O'Connor JM, Illigens BM, Riechelmann RP. Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study. J Clin Med. 2019 Mar 23;8(3):405. doi: 10.3390/jcm8030405. PMID: 30909590; PMCID: PMC6463128.
• Garcia M, Santos-Dias A, Bachi ALL, Oliveira-Junior MC, Andrade-Souza AS, Ferreira SC, Aquino-Junior JCJ, Almeida FM, Rigonato-Oliveira NC, Oliveira APL, Savio LEB, Coutinho-Silva R, Müller T, Idzko M, Siepmann T, Vieira RP. Creatine supplementation impairs airway inflammation in an experimental model of asthma involving P2 × 7 receptor. Eur J Immunol. 2019 Jun;49(6):928-939. doi: 10.1002/eji.201847657. Epub 2019 Apr 18. PMID: 30888047.
• Sofiyeva N, Siepmann T, Barlinn K, Seli E, Ata B. Gonadotropin-Releasing Hormone Analogs for Gonadal Protection During Gonadotoxic Chemotherapy: A Systematic Review and Meta-Analysis. Reprod Sci. 2019 Jul;26(7):939-953. doi: 10.1177/1933719118799203. Epub 2018 Oct 1. PMID: 30270741.
• Pacheco JT, Siepmann T, Barlinn J, Winzer S, Penzlin AI, Puetz V, von der Hagen M, Barlinn K. Safety and efficacy of recanalization therapy in pediatric stroke: A systematic review and meta-analysis. Eur J Paediatr Neurol. 2018 Nov;22(6):1035-1041. doi: 10.1016/j.ejpn.2018.07.013. Epub 2018 Aug 7. PMID: 30122515.
• Fasslrinner F, Schetelig J, Burchert A, Kramer M, Trenschel R, Hegenbart U, Stadler M, Schäfer-Eckart K, Bätzel M, Eich H, Stuschke M, Engenhart-Cabillic R, Krause M, Dreger P, Neubauer A, Ehninger G, Beelen D, Berdel WE, Siepmann T,Stelljes M, Bornhäuser M. Long-term efficacy of reduced-intensity versus myeloablative conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission:retrospective follow-up of an open-label, randomised phase 3 trial. Lancet Haematol. 2018 Apr;5(4):e161-e169. doi: 10.1016/S2352-3026(18)30022-X. Epub 2018 Mar 14. PMID: 29550384.
• Heppt MV, Siepmann T, Engel J, Schubert-Fritschle G, Eckel R, Mirlach L, Kirchner T, Jung A, Gesierich A, Ruzicka T, Flaig MJ, Berking C. Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routinecare. BMC Cancer. 2017 Aug 10;17(1):536. doi: 10.1186/s12885-017-3529-5. PMID: 28797232; PMCID: PMC5553744.
• Riediger C, Schuster T, Barlinn K, Maier S, Weitz J, Siepmann T. Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-analysis. Front Neurol. 2017 Jul 14;8:307. doi: 10.3389/fneur.2017.00307. PMID: 28769859; PMCID: PMC5510574.
• Schnabel A, Range U, Hahn G, Siepmann T, Berner R, Hedrich CM. Unexpectedly high incidences of chronic non-bacterial as compared to bacterial osteomyelitis in children. Rheumatol Int. 2016 Dec;36(12):1737-1745. doi: 10.1007/s00296-016-3572-6. Epub 2016 Oct 11. PMID: 27730289.
• Spieth PM, Kubasch AS, Penzlin AI, Illigens BM, Barlinn K, Siepmann T. Randomized controlled trials - a matter of design. Neuropsychiatr Dis Treat. 2016 Jun 10;12:1341-9. doi: 10.2147/NDT.S101938. PMID: 27354804; PMCID: PMC4910682.
• Nassir M, Guan J, Luketina H, Siepmann T, Rohr I, Richter R, Castillo-Tong DC, Zeillinger R, Vergote I, Van Nieuwenhuysen E, Concin N, Marth C, Hall C, Mahner S, Woelber L, Sehouli J, Braicu EI. The role of HE4 for prediction of recurrence in epithelial ovarian cancer patients-results from the OVCAD study. Tumour Biol. 2016 Mar;37(3):3009-16. doi: 10.1007/s13277-015-4031-9. Epub 2015 Sep 29. PMID: 26419591.
• Seidlitz A, Siepmann T, Löck S, Juratli T, Baumann M, Krause M. Impact of waiting time after surgery and overall time of postoperative radiochemotherapy on treatment outcome in glioblastoma multiforme. Radiat Oncol. 2015 Aug  16;10:172. doi: 10.1186/s13014-015-0478-5. PMID: 26276734; PMCID: PMC4554319.
• Woopen H, Richter R, Chekerov R, Siepmann T, Ismaeel F, Sehouli J. The influence of comorbidity and comedication on grade III/IV toxicity and prior discontinuation of chemotherapy in recurrent ovarian cancer patients: An individual participant data meta-analysis of the North-Eastern German Society of Gynecological Oncology (NOGGO). Gynecol Oncol. 2015 Sep;138(3):735-40. doi:10.1016/j.ygyno.2015.07.007. Epub 2015 Jul 13. PMID: 26185017.
• Lohkamp LN, Öllinger R, Chatzigeorgiou A, Illigens BM, Siepmann T. Intraoperative biomarkers in renal transplantation. Nephrology (Carlton). 2016 Mar;21(3):188-99. doi: 10.1111/nep.12556. PMID: 26132511.